Open AccessShort- and Long-Term Effects of Vitamin D Treatment on Bacillus Calmette-Guerin-Induced Depressive-Like Behavior in Mice
Author(s) -
Lobna A. Saleh,
Farooq M Almutairi,
Wejdan K Alorabi,
Bashayr A Alkuhayli,
Shaden S Alzaidi,
Shahad B Alzahrani,
Futun A Aljumayi,
Maram H. Abduljabbar,
Ayidh S Alharthi,
Mashhour A Alsufyani,
Mohammed H Alhazmi,
Abdulbari A Althobaiti,
Fahad N Almutairi,
Fahad S. Alshehri,
Ebtehal Altowairqi,
Yusuf S. Althobaiti
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s291793
Subject(s) - medicine , vitamin d and neurology , depression (economics) , behavioural despair test , tail suspension test , vitamin , pathogenesis , vitamin d deficiency , physiology , gastroenterology , endocrinology , antidepressant , hippocampus , economics , macroeconomics
Depression is one of the most common psychological disorders. The nutritional etiology of the depression proposes that vitamin D may play a significant role in the pathogenesis of depression. Further, vitamin D deficiency has been found to aggravate depression in animals. Therefore, vitamin D treatment might be a potential therapeutic aid in depression management. This study aimed to explore the antidepressant effects of vitamin D in a Bacillus Calmette-Guerin (BCG)-induced depression model.