Open AccessCircular RNA circPHC3 Promotes Cell Death and Apoptosis in Human BMECs After Oxygen Glucose Deprivation via miR-455-5p/TRAF3 Axis in vitro
Author(s) -
Xiaonan Xu,
Zimu Wu,
Hongyan Qiu,
Jun Wu
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s288669
Subject(s) - apoptosis , gene knockdown , medicine , programmed cell death , in vitro , microbiology and biotechnology , circular rna , stroke (engine) , cell , cancer research , rna , bioinformatics , immunology , biology , gene , biochemistry , mechanical engineering , engineering
Brain microvascular endothelial cells (BMECs) are involved in brain vascular dysfunction in ischemic stroke. Abnormal expression of circular RNAs regulate physiological and pathophysiological processes in the central nervous system. The aim of the present study was to investigate profile circRNAs in human BMECs after oxygen glucose deprivation (OGD), which was an in vitro model of ischemic stroke, and find promising biomarkers in ischemic stroke.