Open AccessEffects of Antipsychotics on Arrhythmogenic Parameters in Schizophrenia Patients: Beyond Corrected QT Interval
Author(s) -
Hiroaki Okayasu,
Takahiro Shinozaki,
Y. Takano,
Norio Sugawara,
Kumiko Fujii,
Norio YasuiFurukori,
Yuji Ozeki,
Kazutaka Saito
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s287042
Subject(s) - levomepromazine , medicine , olanzapine , qt interval , clozapine , quetiapine , antipsychotic , lithium (medication) , cardiology , anesthesia , schizophrenia (object oriented programming) , haloperidol , psychiatry , dopamine
Antipsychotic drugs have been implicated as risk factors for QT prolongation, which is a predictor of sudden cardiac death. However, the QT interval is considered an imperfect marker for proarrhythmic risk. Recently, improved methods, namely, QT dispersion (QTD), QTD ratio (QTDR), T wave peak-to-end interval (Tp-e), Tp-e/QT ratio and Tp-e/QTc ratio, have been regarded as proarrhythmic risk markers. We attempted to reevaluate the risk of sudden cardiac death due to antipsychotics use by measuring these improved evaluation methods.