Open AccessP53/miR-154 Pathway Regulates the Epithelial-Mesenchymal Transition in Glioblastoma Multiforme Cells by Targeting TCF12
Author(s) -
Gang Zhu,
Shirong Yang,
Ronglin Wang,
Jie Lei,
Peigang Ji,
Jiancai Wang,
Kai Tao,
Chen Yang,
Shunnan Ge,
Liang Wang
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s273578
Subject(s) - cancer research , epithelial–mesenchymal transition , microrna , medicine , transcription factor , in vivo , mutant , mutation , downregulation and upregulation , biology , metastasis , gene , cancer , genetics
Glioblastoma multiforme (GBM) is an aggressive brain tumor with a rather short survival time. Mutation of p53 has been observed and reported to play critical roles in the progression of GBM. However, the pathological mechanisms are still unclear. This study was designed to identify the role of miR-154 in mediating the biological functions of p53 in glioblastoma multiforme.