Open Access<p>LncRNA MEG3 Reduces Hippocampal Neuron Apoptosis via the PI3K/AKT/mTOR Pathway in a Rat Model of Temporal Lobe Epilepsy</p>
Author(s) -
Hongyan Zhang,
Jiuyun Tao,
Shuxia Zhang,
Xinxin Lv
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s270614
Subject(s) - pi3k/akt/mtor pathway , tunel assay , epileptogenesis , protein kinase b , terminal deoxynucleotidyl transferase , medicine , hippocampal formation , apoptosis , microbiology and biotechnology , endocrinology , chemistry , biology , immunohistochemistry , biochemistry
Temporal lobe epilepsy (TLE) is a common neurological disorder, which is characterized by recurrent spontaneous seizures. Exploring the mechanisms of epileptogenesis has been considered as a priority. The aim of this study is to investigate the effects of LncRNA MEG3 in spontaneous recurrent epileptiform discharges (SREDs) and rats with TLE.