Open Access<p>Functional Analysis of the 3ʹ Untranslated Region of the Human <em>GRIN1</em> Gene in Regulating Gene Expression in vitro</p>
Author(s) -
Yongping Liu,
Xue Wu,
Meng Jinghua,
Jun Yao,
Baojie Wang
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s268753
Subject(s) - microbiology and biotechnology , gene , untranslated region , transfection , recombinant dna , three prime untranslated region , microrna , receptor , biology , genetics , messenger rna
Abnormal expression of the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor may potentially increase the susceptibility to neuropsychiatric diseases. The purpose of this study was to investigate the functional sequence of the 3'UTR of the human GRIN1 gene, which encodes the GluN1 receptor to determine the effect on the expression of GluN1 receptor.