Open AccessTanshinone IIA Promotes M2 Microglia by ERβ/IL-10 Pathway and Attenuates Neuronal Loss in Mouse TBI Model
Author(s) -
Mingrui Chen,
Qiulin Chen,
Tao Tao
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s265478
Subject(s) - microglia , medicine , traumatic brain injury , macrophage polarization , neuroinflammation , gene knockdown , downregulation and upregulation , pharmacology , arginase , inflammation , immunology , in vitro , apoptosis , macrophage , biology , arginine , biochemistry , amino acid , psychiatry , gene
Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. Increasing evidence indicates that activated microglia play an important role in the inflammatory response in TBI. Inhibiting M1 and stimulating M2 activated microglia have protective effects in several animal models of central nervous system (CNS) disorders. In the present study, we investigated whether tanshinone IIA (TNA) protects neurons by shifting microglia polarization in a mouse TBI model and further investigated the mechanism in vitro.