Open Access<p>Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy</p>
Author(s) -
Lenny Tan,
Yayu Chen,
Wenyue Wu,
Chaorong Liu,
Yujiao Fu,
Jialinzi He,
Min Zhang,
Ge Wang,
Kangrun Wang,
Hongyu Long,
Wenbiao Xiao,
Bo Xiao,
Lili Long
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s258074
Subject(s) - medicine , epilepsy , temporal lobe , cognition , audiology , pediatrics , psychiatry
Patients with temporal lobe epilepsy (TLE) are at high risk of cognitive impairment. In addition to persistent seizures and antiepileptic drugs (AEDs), genetic factors also play an important role in the progression of cognitive deficits in TLE patients. Defining a cognitive endophenotype for TLE can provide information on the risk of cognitive impairment in patients. This study investigated the cognitive endophenotype of TLE by comparing neuropsychological function between patients with TLE, their unaffected siblings, and healthy control subjects.