Open Access<p>Lack of Association Between <em>PLA2G6</em> Genetic Variation and Parkinson’s Disease: A Systematic Review</p>
Author(s) -
Hongmei Li,
Yu Yao,
Hongbo Liu,
Yanmin Peng,
Jun Ren,
Xiaohui Wu,
Ruizhi Mao,
Jie Zhao,
Yuncheng Zhu,
Zhiang Niu,
Tao Yang,
Xiujia Sun,
Ping Jiang,
Chen Zhang,
Yiru Fang
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s254065
Subject(s) - meta analysis , single nucleotide polymorphism , medicine , odds ratio , allele , genetic model , forest plot , genetics , genetic association , parkinson's disease , genetic variation , disease , bioinformatics , genotype , gene , biology
The phospholipase A2 Group 6 ( PLA2G6 , also known as PLA2, PARK14 , and iPLA2 ) gene encodes a group VIA calcium-independent phospholipase A2. Genetic polymorphism of PLA2G6 has been indicated to be involved in conferring susceptibility for Parkinson's disease (PD), whereas conclusive results have not been obtained. Thus, we intended to conduct a systematic review to determine if PLA2G6 genetic variation confers a greater susceptibility to PD.