Open Access<p>Effects of Co-Administration of Icariin and <em>Panax notoginseng</em> Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease</p>
Author(s) -
Ting Zhang,
Keli Dong,
Lan Xiao,
Guangcheng Li,
Zhanwei Zhang
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s253972
Subject(s) - panax notoginseng , icariin , morris water navigation task , western blot , medicine , genetically modified mouse , hippocampal formation , microbiology and biotechnology , real time polymerase chain reaction , transgene , pharmacology , endocrinology , biology , biochemistry , pathology , alternative medicine , gene
We investigated the effect of icariin (ICA) combined with Panax notoginseng saponins (PNS) on intestinal microbiota and hippocampal protein expression in amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice, a model of Alzheimer's disease (AD).