Open Access<p>Interrelation Between Increased BDNF Gene Methylation and High Sociotropy, a Personality Vulnerability Factor in Cognitive Model of Depression</p>
Author(s) -
Toshinori Shirata,
Akihito Suzuki,
Yoshihiko Matsumoto,
Keisuke Noto,
Kaoru Goto,
Koichi Otani
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s252177
Subject(s) - psychology , dna methylation , cognitive vulnerability , cognition , brain derived neurotrophic factor , methylation , developmental psychology , neurotrophic factors , medicine , clinical psychology , genetics , gene , psychiatry , gene expression , biology , depressive symptoms , receptor
It is suggested that increased methylation of the brain-derived neurotrophic factor (BDNF) gene is involved in the pathogenesis of depression, while sociotropy and autonomy are proposed as personality vulnerability factors in cognitive model of depression. We examined the interrelation between BDNF gene methylation and sociotropy or autonomy, with taking into account the previously reported deleterious effect of parental overprotection on sociotropy.