Open Access<p>MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3</p>
Author(s) -
Yu Xue,
Dehao Zeng,
He Zhu,
Yijing Zhang,
Yuying Shi,
Yingxiu Wu,
Hongmei Tang,
Detang Li
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s251152
Subject(s) - proinflammatory cytokine , tail suspension test , behavioural despair test , medicine , stat3 , microrna , blot , microglia , tumor necrosis factor alpha , microbiology and biotechnology , hippocampus , signal transduction , inflammation , biology , gene , biochemistry , antidepressant
It is known that miR-532-5p is critical for neuronal differentiation. However, the role of miR-532-5p in depression remains unknown. This study aimed to investigate the role and mechanism of miR-532-5p in major depressive disorder (MDD).