Open Access<p>Impact of Expression and Genetic Variation of microRNA-34b/c on Cognitive Dysfunction in Patients with Major Depressive Disorder</p>
Author(s) -
Ning Sun,
Chunxia Yang,
Xuesong He,
Zhifen Liu,
Sha Li,
Xinrong Li,
Yanfang Wang,
Ruihua Jin,
Kerang Zhang
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s247787
Subject(s) - repeatable battery for the assessment of neuropsychological status , major depressive disorder , medicine , cognition , single nucleotide polymorphism , microrna , effects of sleep deprivation on cognitive performance , neuropsychology , population , oncology , snp , clinical psychology , bioinformatics , genotype , psychiatry , genetics , gene , biology , environmental health
Patients suffering from major depressive disorder (MDD) commonly demonstrate lower performance across multiple cognitive domains. Cognitive impairment is an intrinsic characteristic of MDD status and is often influenced by genetic factors. microRNAs (miRNAs or miRs) have been shown to have important implications in the etiology of MDD. Therefore, we aimed to identify and analyze the impact of expression and genetic variation of miR-34b/c on cognitive dysfunction in MDD.