Open Access<p>Intranasal Delivery of miR-155-5p Antagomir Alleviates Acute Seizures Likely by Inhibiting Hippocampal Inflammation</p>
Author(s) -
Xu Zhou,
Jun Chen,
Hua Tao,
Yujie Cai,
Lidan Huang,
Haihong Zhou,
Yanyan Chen,
Lili Cui,
Wangtao Zhong,
Keshen Li
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s247677
Subject(s) - antagomir , medicine , hippocampal formation , epilepsy , proinflammatory cytokine , nasal administration , microglia , inflammation , hippocampus , pharmacology , microrna , immunology , biology , biochemistry , psychiatry , gene
To confront the resistance to existing antiepileptic drugs, studies have gradually begun to investigate alternative pathologies distinct from the traditional treatments that overwhelmingly target ion channels. Microglia activation is the first inflammatory response in the brain, in which miR-155-5p plays a key proinflammatory role and thus represents a promising target for inflammatory modulation in epilepsy pathologies.