Open Access<p>Protective Effects of <em>Spirulina platensis</em>, Voluntary Exercise and Environmental Interventions Against Adolescent Stress-Induced Anxiety and Depressive-Like Symptoms, Oxidative Stress and Alterations of BDNF and 5HT-3 Receptors of the Prefrontal Cortex in Female Rats</p>
Author(s) -
Nasroallah Moradi Kor,
Masoomeh Dadkhah,
Ali Ghanbari,
Hadi Rashidipour,
Ahmad Reza Bandegi,
Mehdi Barati,
Parviz Kokhaei,
Ali Rashidy-Pour
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s247599
Subject(s) - oxidative stress , medicine , anxiety , malondialdehyde , lipid peroxidation , endocrinology , superoxide dismutase , antioxidant , psychiatry , biology , biochemistry
Ample evidence indicates that chronic adolescence stress is associated with an increased risk of developing neuropsychiatric disorders in adulthood. Given the importance of the effective therapeutic ways to overcome adolescent stress-related deficits, the present study investigated the effects of Spirulina platensis (SP), environmental enrichment (EE), and voluntary exercise (EX) and their combination on anxiety or depression-like behaviors, oxidative stress, and alterations of BDNF and 5HT-3 receptors in the prefrontal cortex (PFC) induced by adolescent stress in adult female rats.