Open Access<p>miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus</p>
Author(s) -
Cuixia Li,
Rui Wang,
Miao Pei,
Li Yan,
Silin Liu,
Xian Wang,
Zuolin Jin,
Zhenyong Gu
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s237558
Subject(s) - gene knockdown , hippocampus , downregulation and upregulation , microrna , behavioural despair test , medicine , blot , major depressive disorder , reporter gene , microbiology and biotechnology , endocrinology , biology , gene expression , gene , genetics , antidepressant , amygdala
Major depressive disorder (MDD) is a serious and common mood disorder with unknown etiology. Emerging evidence has demonstrated the critical roles of SIRT1 and microRNAs (miRNAs) in the progression of MDD. However, the underlying molecular mechanisms remain to be fully understood.