Open Access<p>Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease</p>
Author(s) -
Shanshan Hu,
Meigui Hu,
Jian Liu,
Bei Zhang,
Zhen Zhang,
Fiona H. Zhou,
Liping Wang,
Jianghui Dong
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s235562
Subject(s) - neurodegeneration , substantia nigra , mptp , parkinson's disease , hyperphosphorylation , lewy body , medicine , neuroscience , alpha synuclein , tau protein , tyrosine hydroxylase , dopaminergic , synuclein , hippocampus , pathology , phosphorylation , immunohistochemistry , biology , alzheimer's disease , dopamine , microbiology and biotechnology , disease
Parkinson's disease (PD) is the second most common neurodegenerative disease. The α-Synuclein is a major component of Lewy bodies and Lewy neurites, the pathologic hallmark of PD. It is known that α-Synuclein is phosphorylated (p-α-Synuclein) in PD and tau-hyperphosphorylation (p-Tau) is also a pathologic feature of PD. However, the relationship between p-Synuclein and p-Tau in PD is not clear, in particular in the MPTP model of PD. The purpose of this study was to reveal their relationship in the mouse MPTP model.