Open AccessMissense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population
Author(s) -
Birsen Demirdöğen,
Yağmur Miçooğulları,
Aysun Türkanoğlu Özçelik,
Orhan Adalı
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s233992
Subject(s) - medicine , single nucleotide polymorphism , epoxide hydrolase 2 , turkish population , population , microsomal epoxide hydrolase , stroke (engine) , genotype , pathology , endocrinology , gastroenterology , cardiology , genetics , epoxide hydrolase , biology , gene , biochemistry , microsome , mechanical engineering , environmental health , engineering , in vitro , enzyme
Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury owing to their participation in the regulation of vascular tone and cerebral blood flow. In addition, mEH metabolizes polycyclic aromatic hydrocarbons, one of the causative factors of atherosclerotic lesion development. In this study, we aimed to investigate the association of enzyme activity-modifying missense single nucleotide polymorphisms (SNPs) of the sEH gene ( EPHX2 ) and mEH gene ( EPHX1 ) and ischemic stroke risk in a Turkish population.