Open Access<p>K-3-Rh Protects Against Cerebral Ischemia/Reperfusion Injury by Anti-Apoptotic Effect Through PI3K-Akt Signaling Pathway in Rat</p>
Author(s) -
Juan Sun,
Jian Wang,
Luoman Hu,
Jinfeng Yan
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s233622
Subject(s) - medicine , apoptosis , pi3k/akt/mtor pathway , tunel assay , protein kinase b , neuroprotection , wortmannin , reperfusion injury , pharmacology , ischemia , western blot , immunohistochemistry , chemistry , biochemistry , gene
Ischemic stroke is the main cause of nerve damage and brain dysfunction, accompanied by strong brain cell apoptosis. This study aimed to investigate the effect of kaempferol-3-O-rhamnoside (K-3-rh) on cerebral ischemia-reperfusion (I/R) injury.