Open Access<p>Real-World Effectiveness and Safety of Antipsychotics in Individuals at Clinical High-Risk for Psychosis: Study Protocol for a Prospective Observational Study (ShangHai at Risk for Psychosis-Phase 2)</p>
Author(s) -
GuiSen Wu,
RanPiao Gan,
Zhixing Li,
Li-Hua Xu,
Xiaochen Tang,
Yanyan Wei,
YeGang Hu,
HuiRu Cui,
Huijun Li,
Yingying Tang,
Hui Li,
Xiaohua Liu,
Chunbo Li,
Jijun Wang,
Tianhong Zhang
Publication year - 2019
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s230904
Subject(s) - medicine , psychiatry , observational study , psychosis , antipsychotic , schizophrenia (object oriented programming)
The clinical high-risk (CHR) state is identified as a critical period for early prevention and intervention during the development of psychosis and early treatment may reduce the risk of conversion to psychosis. However, it remains controversial whether antipsychotics are effective in CHR populations. Limited previous randomised controlled trials of antipsychotic treatment of CHR individuals indicated possible short-term efficacy on psychotic symptoms with unclear long-term effects. To answer this question, it is necessary to establish a high-quality real-world cohort study with large sample size to explore the effectiveness and safety of antipsychotics in CHR individuals.