Open Access<p>A Study of Antidepressant Effect and Mechanism on Intranasal Delivery of BDNF-HA2TAT/AAV to Rats with Post-Stroke Depression</p>
Author(s) -
Ce Chen,
Yingying Dong,
Fei Liu,
Chengge Gao,
Ji Cui,
Yonghui Dang,
Xiancang Ma,
Yong Liu
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s227598
Subject(s) - medicine , neurotrophic factors , hippocampus , behavioural despair test , prefrontal cortex , brain derived neurotrophic factor , endocrinology , antidepressant , neuroplasticity , depression (economics) , pathophysiology , receptor , psychiatry , cognition , macroeconomics , economics
Post-stroke depression (PSD) is one of the most frequent neuropsychiatric disorders associated with stroke characterized by depression. The neuroplasticity hypothesis postulates that loss of brain-derived neurotrophic factor (BDNF) plays a major role in pathophysiology of PSD, and restoration of it may represent a critical mechanism underlying antidepressant efficacy.