Open Access<p>Association of Clusterin Levels in Cerebrospinal Fluid with Synaptic Degeneration Across the Alzheimer’s Disease Continuum</p>
Author(s) -
Jun Wang,
Xin Zhang,
Bihong Zhu,
Pan Fu
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s224877
Subject(s) - clusterin , neurogranin , medicine , neuropathology , alzheimer's disease , disease , cognition , cerebrospinal fluid , confounding , oncology , neuroscience , psychiatry , psychology , biology , apoptosis , genetics , protein kinase c , phosphorylation
Although emerging evidence has suggested that clusterin is involved in the pathogenesis of Alzheimer's disease (AD), the association of clusterin with synaptic degeneration in living human is unclear. In the present study, we aimed to examine the association of CSF clusterin levels with synaptic degeneration in individuals with different severities of cognitive impairment.