Open Access<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
Author(s) -
Fan Wang,
Shunying Yu,
Rubai Zhou,
Ruizhi Mao,
Guangsheng Zhao,
Xiaoyun Guo,
Qingqing Xu,
Jun Chen,
Chen Zhang,
Yiru Fang
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s222906
Subject(s) - haplotype , single nucleotide polymorphism , major depressive disorder , medicine , genetics , snp , genotyping , insulin resistance , genotype , mental illness , gene , psychiatry , insulin , biology , mental health , amygdala
Major depressive disorder (MDD) is one of the most prevalent and disabling mental disorders, although its underlying genetic mechanism remains unknown. Insulin receptor substrate-1 (IRS-1) is one of the critical downstream molecules in the insulin resistance signaling pathway, linking depression and diabetes. Therefore, we hypothesized that IRS-1 would be a susceptible gene for MDD, and we aimed to examine the genetic association between IRS-1 and MDD.