Open Access<p>UPLC-Q-TOF-MS profiling of the hippocampus reveals metabolite biomarkers for the impact of Dl-3-n-butylphthalide on the lipopolysaccharide-induced rat model of depression</p>
Author(s) -
Chunmei Geng,
Yujin Guo,
Yi Qiao,
Jun Zhang,
Dan Chen,
Wenxiu Han,
Mengqi Yang,
Pei Jiang
Publication year - 2019
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s203870
Subject(s) - metabolite , medicine , hippocampal formation , lipopolysaccharide , hippocampus , inflammation , pharmacology , metabolomics , pathophysiology , depression (economics) , oxidative stress , endocrinology , bioinformatics , biology , economics , macroeconomics
An increasing body of evidence reveals that inflammation is involved in the pathological mechanisms of depression. Our previous basic research confirmed that Dl-3-n-butylphthalide (NBP) possess anti-inflammatory properties. However, studies investigating metabolite biomarkers for the involvement of NBP in hippocampus tissue in the lipopolysaccharide (LPS)-induced rat model of depression are currently limited. Thus, the aim of this study was to identify metabolite biomarkers in the hippocampus for the impact of NBP in this model of depression.