Open Access<p>In vitro and in vivo Evaluation of the Efficacy and Safety of Powder Hydroxypropylmethylcellulose as Nasal Mucosal Barrier</p>
Author(s) -
Todor A. Popov,
Jean Emberlin,
Peter Josling,
Alexander M. Seifalian
Publication year - 2020
Publication title -
medical devices
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.482
H-Index - 30
ISSN - 1179-1470
DOI - 10.2147/mder.s236104
Subject(s) - in vivo , inhalation , in vitro , allergen , ragweed , insufflation , nasal administration , pharmacology , medicine , chemistry , pathology , immunology , anesthesia , allergy , biology , biochemistry , microbiology and biotechnology
Insufflation of powder hydroxypropylmethylcellulose (pHPMC) in the nose has been proven an effective barrier in subjects with rhinitis in many clinical studies. We conducted additionally in vitro and in vivo experiments to address outstanding efficacy and safety issues.