Open AccessRepeated Sevoflurane Exposure in Neonatal Rats Enhances the Sensitivity to Pain and Traumatic Stress Later in Juvenile Life
Author(s) -
Ben-Zhen Chen,
Jiang Li,
Wen-qin Zhou,
Yu-chao Shang,
Fang Li,
Bin Liu
Publication year - 2022
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s365253
Subject(s) - medicine , juvenile , sevoflurane , traumatic stress , anesthesia , psychiatry , genetics , biology
Sevoflurane exposure in the neonatal period of rodent animals was reported to be associated with neuroendocrine dysregulations later in life. We tested the hypothesis that repeated sevoflurane exposure in neonatal rats enhances the sensitivity to pain and acute traumatic stress response later in juvenile life and investigated whether the neonatal brain depolarizing γ-aminobutyric acid type A receptor (GABA A R) activity is involved in mediating these abnormalities.