Open AccessGenome-Wide Expression Profiling by RNA-Sequencing in Spinal Cord Dorsal Horn of a Rat Chronic Postsurgical Pain Model to Explore Potential Mechanisms Involved in Chronic Pain
Author(s) -
Ruoyao Xu,
Jie Wang,
Huimin Nie,
Danyi Zeng,
Chengyu Yin,
Yuanyuan Li,
Huina Wei,
Boyu Liu,
Yan Tai,
Qimiao Hu,
Xiaomei Shao,
Jianqiao Fang,
Boyi Liu
Publication year - 2022
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s358942
Subject(s) - chronic pain , medicine , spinal cord , rna , gene , immunostaining , neuroscience , gene expression , gene expression profiling , allodynia , bioinformatics , receptor , hyperalgesia , pathology , biology , genetics , nociception , immunohistochemistry , psychiatry
Chronic postsurgical pain (CPSP) is common among patients receiving major surgeries. CPSP produces suffering in patients, both physically and mentally. However, the mechanisms underlying CPSP remain elusive. Here, a genome-wide expression profiling of ipsilateral spinal cord dorsal horn (SCDH) was performed to identify potential genes related with CPSP.