Open AccessViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels
Author(s) -
K Venkatakrishna,
K Sundeep,
Sudeep HV,
Kuluvar Gouthamchandra,
Kodimule Shyamprasad
Publication year - 2022
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s351513
Subject(s) - trpv1 , cannabinoid receptor type 2 , licking , pharmacology , capsazepine , tail flick test , nociception , medicine , cannabinoid receptor , agonist , tail suspension test , capsaicin , cannabinoid , receptor , behavioural despair test , transient receptor potential channel , hippocampus , antidepressant
Plant-based natural products as anti-nociceptors have enormous potential as safer alternatives to conventional opiates and NSAIDS. Piper nigrum (black pepper) is one of the major culinary spices with medicinal attributes.