Open AccessQX-OH/Levobupivacaine: A Structurally Novel, Potent Local Anesthetic Produces Fast-Onset and Long-Lasting Regional Anesthesia in Rats
Author(s) -
Yang Yang,
Chiyi Wang,
Jin Liu,
Daqing Liao,
Wensheng Zhang,
Cheng Zhou
Publication year - 2022
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s343500
Subject(s) - levobupivacaine , medicine , in vivo , anesthesia , anesthetic , local anesthetic , toxicity , in vitro , pharmacology , analgesic , biochemistry , chemistry , microbiology and biotechnology , biology
Local anesthetics (LAs) are an important alternative for postoperative analgesia; however, the short duration of LAs limits their use. Thus, we previously developed LL-1, a mixture of QX-OH and levobupivacaine (LB) that produces regional anesthesia for more than 10 h in rats. The aim of this study is to investigate the long-acting mechanism of LL-1 in vivo and in vitro.