Open AccessPuerarin Attenuates Complete Freund’s Adjuvant-Induced Trigeminal Neuralgia and Inflammation in a Mouse Model via Sirt1-Mediated TGF-β1/Smad3 Inhibition
Author(s) -
Kairong Du,
Wei Wu,
Xiaobo Feng,
Jianjuan Ke,
Hengtao Xie,
Yingying Chen
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s323588
Subject(s) - medicine , puerarin , pharmacology , neuroprotection , inflammation , tunel assay , downregulation and upregulation , tumor necrosis factor alpha , proinflammatory cytokine , apoptosis , immunology , pathology , biology , biochemistry , immunohistochemistry , alternative medicine , gene
Puerarin, an active compound of radix puerariae, is a major compound used in Chinese herbal medicines and it has been well known for its pharmacological effects, including antioxidant, anti‑inflammatory, neuroprotective and cardioprotective properties. The aim of the present study was to determine the role of puerarin (Pue) in complete Freund's adjuvant (CFA)-induced trigeminal neuralgia (TN) and the effects of this compound on Sirt1 activity and on the progression of CFA-induced TN.