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Screening and Identification of Key Genes, Pathways, and Drugs Associated with Neuropathic Pain in Dorsal Horn: Evidence from Bioinformatic Analysis
Author(s) -
Xiao Yang,
Lin Zhu,
Bing-Cheng Zhao,
Jianping Hu,
Fan Deng,
Shao-Hui Lei,
Zhiwen Yao,
Ke-Xuan Liu
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s312117
Subject(s) - neuropathic pain , medicine , microarray analysis techniques , gene , microarray , gene ontology , transcription factor , bioinformatics , computational biology , gene expression , pharmacology , genetics , biology
Neuropathic pain is a devastating complex condition occurring post-nervous system damage. Microglia in dorsal horn drives neuropathic pain as a kind of immune cell. We aimed to find potential differentially expressed genes (DEGs) and candidate pathways, which induced neuropathic pain, and to identify some new transcription factors and therapeutic drugs via bioinformatic analysis.

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