Open AccessErbB4 in Spinal PV Interneurons Regulates Mechanical Allodynia in Neuropathic Pain via Modulation of Glycinergic Inhibitory Tone
Author(s) -
Ying-Ying Yu,
Guohua Wei,
Qiongqiong Zhou,
Huanhuan Sha
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s311894
Subject(s) - neuropathic pain , allodynia , medicine , inhibitory postsynaptic potential , glycine receptor , spinal cord , nociception , neuroscience , erbb4 , hyperalgesia , anesthesia , receptor , glycine , biology , biochemistry , amino acid , psychiatry , receptor tyrosine kinase
Mechanical allodynia is the most common and challenging symptom associated with neuropathic pain; however, the underlying mechanisms are still unclear. The aim of this study was to investigate whether ErbB4, a receptor for neuregulin-1 (NRG1), participates in the modulation of mechanical allodynia.