Open AccessFibromyalgia and Nociceptive Flexion Reflex (NFR) Threshold: A Systematic Review, Meta-Analysis, and Identification of a Possible Source of Heterogeneity
Author(s) -
Masoud Amiri,
Jamie L. Rhudy,
Kei Masani,
Dinesh Kumbhare
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s306403
Subject(s) - meta analysis , medicine , fibromyalgia , systematic review , psycinfo , data extraction , medline , physical medicine and rehabilitation , reflex , randomized controlled trial , cochrane library , publication bias , physical therapy , anesthesia , political science , law
The nociceptive flexion reflex is a physiological, polysynaptic reflex and refers to the level that an appropriate withdrawal response activates when a painful stimulus is detected. The nociceptive flexion reflex threshold (NFRthr) is defined as the lowest noxious stimulation intensity required to trigger a reflex motor response. Despite wide utilization and reports of the NFRthr, there has been no consensus on a standard and/or best method in assessment of the NFRthr.