Open AccessUlinastatin Exhibits Antinociception in Rat Models of Acute Somatic and Visceral Pain Through Inhibiting the Local and Central Inflammation
Author(s) -
Mei-Xiang Zhan,
Li Tang,
Yao Lu,
Huang-Hui Wu,
Zhi-Bin Guo,
Zhong-Mou Shi,
Chen-Long Yang,
Yi-Qing Zou,
Fei Yang,
Guozhong Chen
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s303595
Subject(s) - ulinastatin , medicine , analgesic , anesthesia , h&e stain , pharmacology , nociception , visceral pain , inflammation , licking , pathology , immunohistochemistry , receptor
Ulinastatin, a broad-spectrum serine protease inhibitor, has been widely used to treat various diseases clinically. However, so far, the antinociceptive effect of ulinastatin remains less studied experimentally and the underlying mechanisms of ulinastatin for pain relief remain unclear. This study aimed to find evidence of the analgesic effect of ulinastatin on acute somatic and visceral pain.