Open AccessRepeat Epidural Injections of SP-102 (Dexamethasone Sodium Phosphate Injectable Gel) in Subjects with Lumbosacral Radiculopathy
Author(s) -
Richard Radnovich,
Jill Heinz,
Christopher S. Ambrose,
Elizabeth Stannard,
Dmitri Lissin
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s303282
Subject(s) - medicine , dexamethasone sodium phosphate , adverse effect , dexamethasone , lumbosacral joint , anesthesia , epidural steroid injection , saline , dosing , low back pain , surgery , alternative medicine , pathology
SP-102 is a novel epidural steroid injection (ESI) formulation of 10 mg dexamethasone sodium phosphate in a viscous gel solution. Repeat dosing of ESIs is possible if required for pain relief, but with consideration of hypothalamic-pituitary-adrenal (HPA) axis suppression from prolonged systemic exposure. This phase I/II study investigated the effect of initial and repeat SP-102 injections on HPA suppression and analgesia.