Open AccessLow-Dose Interleukin-2 and Regulatory T Cell Treatments Attenuate Punctate and Dynamic Mechanical Allodynia in a Mouse Model of Sciatic Nerve Injury
Author(s) -
Rong Hu,
Jintao Zhang,
Xuemei Liu,
Dong Huang,
Yu Qing Cao
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s301343
Subject(s) - sni , medicine , allodynia , adoptive cell transfer , nerve injury , regulatory t cell , sciatic nerve , immunology , t cell , anesthesia , hyperalgesia , pharmacology , immune system , nociception , il 2 receptor , receptor , biology , biochemistry , hydrolysis , acid hydrolysis
Nerve injury-induced mechanical hyper-sensitivity, in particular stroking-induced dynamic allodynia, is highly debilitating and difficult to treat. Previous studies indicate that the immunosuppressive regulatory T (Treg) cells modulate the magnitude of punctate mechanical allodynia resulting from sciatic nerve injury. However, whether enhancing Treg-mediated suppression attenuates dynamic allodynia is not known. In the present study, we addressed this knowledge gap by treating mice with low-dose interleukin-2 (ld-IL2) injections or adoptive transfer of Treg cells.