Open AccessEffects of Polymorphisms in the Serotonin Transporter Promoter-Linked Polymorphic Region on Postthoracotomy Pain Severity
Author(s) -
Aya Kimura,
Hiroyuki Yamasaki,
Haruka Ishii,
Haruhiko Yoshida,
Motoko Shimizu,
Takashi Mori
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s298685
Subject(s) - 5 httlpr , medicine , serotonin transporter , genotype , allele , polymorphism (computer science) , chronic pain , anesthesia , serotonin , gene , genetics , physical therapy , receptor , biology
Serotonin (5-HT) is highly associated with pain modulation. The human 5-HT transporter (5-HTT) gene (SLC6A4) features several polymorphisms in its promoter region (5-HTTLPR) that affect the 5-HTT expression. The S allele of 5-HTTLPR induces low 5-HT tone, and it may influence the modulation of chronic pain. Meanwhile, pain occurs in 40-50% of patients after thoracic surgery, and its mechanism remains under investigation. This study assessed the role of 5-HTTLPR polymorphisms in postthoracotomy pain severity.