Open AccessDopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine
Author(s) -
Dajung J. Kim,
Hassan Jassar,
Manyoel Lim,
Thiago D. Nascimento,
Alexandre F. DaSilva
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s296540
Subject(s) - medicine , dopaminergic , migraine , neuroscience , reward system , psychiatry , dopamine , biology
It has been suggested that reward system dysfunction may account for emotion and pain suffering in migraine. However, there is a lack of evidence whether the altered reward system connectivity is directly associated with clinical manifestations, including negative affect and ictal pain severity and, at the molecular level, the dopamine (DA) D2/D3 receptors (D2/3Rs) signaling implicated in encoding motivational and emotional cues.