Open AccessSingle and Repeated Intrapleural Ropivacaine Administration: A Plasma Concentration and Pharmacodynamics Study
Author(s) -
Yuanqing Chen,
Yingying Cai,
Yingchao Ye,
Yun Xia,
Thomas J Papadimos,
Le Liu,
Xuzhong Xu,
Quanguang Wang,
Kenrin Shi,
Yiquan Wu
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s295913
Subject(s) - medicine , ropivacaine , anesthesia , analgesic , epidural administration , adverse effect , morphine , pharmacokinetics , chest tube , pharmacodynamics , patient satisfaction , surgery , pneumothorax
Intrapleural analgesia has been increasingly recommended for postoperative analgesia after thoracic surgery. However, the analgesic effect provided by a single intrapleural administration is time limited. This study reports the efficacy and safety of repeated intrapleural 0.75% ropivacaine administration after thoracoscopic surgery.