Open AccessProteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway
Author(s) -
Peng Chen,
Dongsheng Lin,
Chen Wang,
Cuiwen Song,
Wenjing Wang,
Jinglian Qu,
Zhibing Wu
Publication year - 2021
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s290681
Subject(s) - emodin , kegg , signal transduction , medicine , protein kinase c , western blot , calcium signaling , calmodulin , camk , protein kinase a , microbiology and biotechnology , phosphorylation , pharmacology , biology , biochemistry , gene expression , calcium , gene , transcriptome , autophosphorylation
Neuropathic pain (NP) is a syndrome of pain mediated by distinct pathophysiological processes, and current treatments are not fully satisfactory. Emodin is an effective component of Chinese traditional medicine and has an alleviating effect on NP, but the pharmacological mechanism is not clear.