Open AccessCurcumin Improves Chronic Pain Induced Depression Through Regulating Serum Metabolomics in a Rat Model of Trigeminal Neuralgia
Author(s) -
Li Zhang,
Zhijie Ma,
Zhe Wu,
Mu Jin,
Li-Xin An,
FuShan Xue
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s283782
Subject(s) - medicine , chronic pain , trigeminal neuralgia , allodynia , behavioural despair test , neuropathic pain , anhedonia , neuralgia , depression (economics) , curcumin , pharmacology , antidepressant , anesthesia , nociception , hippocampus , dopamine , psychiatry , hyperalgesia , receptor , macroeconomics , economics
Depression is a prevalent and complex psychiatric disorder with high incidence in patients with chronic pain. The underlying pathogenesis of chronic pain-induced depression is complicated and remains largely unclear. An integrated analysis of endogenous substance-related metabolisms would help to understand the molecular mechanism of chronic pain-induced depression. Curcumin was reported to exert various health benefits, such as anti-depression, antioxidant, antineoplastic, analgesia, and anti-inflammation.