Open Access<p>Intravenous Administration of Triptonide Attenuates CFA-Induced Pain Hypersensitivity by Inhibiting DRG AKT Signaling Pathway in Mice</p>
Author(s) -
Yuejuan Ling,
TingYu Ding,
Fenglin Dong,
YongJing Gao,
BaoChun Jiang
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s275320
Subject(s) - medicine , protein kinase b , pharmacology , hyperalgesia , proinflammatory cytokine , edema , tumor necrosis factor alpha , inflammation , immunology , nociception , signal transduction , receptor , biochemistry , chemistry
Currently, medical treatment of inflammatory pain is limited by a lack of safe and effective therapies. Triptonide (TPN), a major component of Tripterygium wilfordii Hook.f . with low toxicity, has been shown to have good anti-inflammatory and neuroprotective effects. The present study aims to investigate the effects of TPN on chronic inflammatory pain.