Open Access<p>Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain</p>
Author(s) -
Yanyun Ma,
Xinye Zhang,
Changsheng Li,
Sufang Liu,
Ying Xing,
Feng Tao
Publication year - 2020
Publication title -
journal of pain research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s267778
Subject(s) - creb , medicine , chronic pain , spinal cord , anesthesia , endocrinology , biology , physical therapy , psychiatry , biochemistry , gene , transcription factor
It has been reported that N-cadherin and cAMP response element binding protein (CREB) in the spinal cord are critical for synaptogenesis and regulation of excitatory synapse function, which could underlie chronic pain development. The aim of the present study was to investigate the role of spinal N-cadherin/CREB signaling in postsurgical pain chronicity following chronic alcohol consumption.