Open Access<p>Intraneural Application of microRNA-1 Mimetic Nucleotides Does Not Resolve Neuropathic Pain After Chronic Constriction Injury in Rats</p>
Author(s) -
Anne Kuebart,
Verena Wollborn,
Ragnar Huhn,
Henning Hermanns,
Robert Werdehausen,
Timo Brandenburger
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s266937
Subject(s) - medicine , constriction , neuropathic pain , microrna , chronic pain , bioinformatics , anesthesia , physical therapy , gene , biochemistry , chemistry , biology
Alterations of the expression of microRNAs (miRNAs) in chronic pain models seem to play a crucial role in the development of neuropathic pain, with microRNA-1 (miR-1) being of particular interest. Recently, we were able to show that decreased miR-1 levels were associated with increased expression of brain-derived neurotrophic factor (BDNF) and Connexin 43 (Cx43). We hypothesized that miR-1 mimetic nucleotides could alleviate neuropathic pain caused by chronic constriction injury in rats.