Open AccessInterleukin-10 Reduces Neurogenic Inflammation and Pain Behavior in a Mouse Model of Type 2 Diabetes
Author(s) -
Brandon M. Yanik,
Jacqueline R. Dauch,
Hong Cheng
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s264136
Subject(s) - medicine , inflammation , type 2 diabetes , neurogenic inflammation , diabetes mellitus , neuroscience , immunology , endocrinology , substance p , receptor , neuropeptide , biology
Neurogenic inflammation is a major component of chronic neuropathic pain. Previously, we established the db/db mouse as an animal model of painful diabetic neuropathy (PDN) of type 2 diabetes. In the current study, we investigate the roles of interleukin (IL)-10, an anti-inflammatory cytokine, in the development of neurogenic inflammation and pain behavior in db/db mouse.