Open Access<p>Development and Prospect of Intra-Articular Injection in the Treatment of Osteoarthritis: A Review</p>
Author(s) -
Zhang Yin,
Xinji Chen,
Tong Yu,
Junchao Luo,
Qing Bi
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s260878
Subject(s) - medicine , osteoarthritis , intra articular , hyaluronic acid , stromal vascular fraction , platelet rich plasma , adverse effect , mesenchymal stem cell , viscosupplementation , surgery , physical therapy , pathology , platelet , alternative medicine , anatomy
Osteoarthritis (OA) is a common degenerative disease that affects the vast majority of the elderly and may eventually embark on the road of the total knee arthroplasty (TKA), although controversy still exists in the medical community about the best therapies for osteoarthritis. Compared with physical therapy, oral analgesics and other non-operative treatments, intra-articular injection is more safe and effective. Moreover, intra-articular injection is much less invasive and has fewer adverse reactions than surgical treatment. This article reviews mechanism, benefits and adverse reactions of corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), mesenchymal stem cell (MSCs), stromal vascular fraction (SVF) and other new therapies (for example: gene therapy). The application prospect of intra-articular injection was analyzed according to the recent progress in drug research.