Open Access<p>Role of the CXCR4/ALK5/Smad3 Signaling Pathway in Cancer-Induced Bone Pain</p>
Author(s) -
Chong Peng,
Xue-Tai Chen,
Heng Xu,
Chen Li-ping,
Wen Shen
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s260508
Subject(s) - medicine , cxcr4 , neuropathic pain , hyperalgesia , nociception , small interfering rna , chemokine , spinal cord , cancer research , chemokine receptor , receptor , signal transduction , pharmacology , microbiology and biotechnology , biology , rna , biochemistry , gene , psychiatry
The chemokine receptor, CXCR4, and the transforming growth factor-beta receptor, ALK5, both contribute to various processes associated with the sensation of pain. However, the relationship between CXCR4 and ALK5 and the possible mechanisms promoted by ALK5 in the development of pain have not been evaluated.