Open Access<p>Hyperalgesia and Reduced Offset Analgesia During Spinal Anesthesia</p>
Author(s) -
Elske Sitsen,
Monique van Velzen,
Mischa de Rover,
Albert Dahan,
Marieke Niesters
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s258533
Subject(s) - medicine , anesthesia , hyperalgesia , noxious stimulus , anesthetic , nociception , receptor
Spinal anesthesia induces short-term deafferentation and causes connectivity changes in brain areas involved in endogenous pain modulation. We determined whether spinal anesthesia alters pain sensitivity and offset analgesia. Offset analgesia is a manifestation of endogenous pain modulation and characterized by profound analgesia upon a small decrease in noxious stimulation.