Open Access<p>CBD Effects on TRPV1 Signaling Pathways in Cultured DRG Neurons</p>
Author(s) -
Uma Anand,
Ben Jones,
Yuri Korchev,
Stephen R. Bloom,
Barbara Pacchetti,
Praveen Anand,
Mikael H. Sodergren
Publication year - 2020
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s258433
Subject(s) - forskolin , trpv1 , medicine , adenylyl cyclase , capsaicin , dorsal root ganglion , pharmacology , desensitization (medicine) , endocrinology , receptor , transient receptor potential channel , anatomy , dorsum
Cannabidiol (CBD) is reported to produce pain relief, but the clinically relevant cellular and molecular mechanisms remain uncertain. The TRPV1 receptor integrates noxious stimuli and plays a key role in pain signaling. Hence, we conducted in vitro studies, to elucidate the efficacy and mechanisms of CBD for inhibiting neuronal hypersensitivity in cultured rat sensory neurons, following activation of TRPV1.