Open Access<p>Preemptive Nalbuphine Attenuates Remifentanil-Induced Postoperative Hyperalgesia After Laparoscopic Cholecystectomy: A Prospective Randomized Double-Blind Clinical Trial</p>
Author(s) -
Jun Hu,
Shuangshuang Chen,
Mudan Zhu,
Yun Wu,
Ping Wang,
Jinbao Chen,
Ye Zhang
Publication year - 2020
Publication title -
journal of pain research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s257018
Subject(s) - remifentanil , nalbuphine , medicine , anesthesia , hyperalgesia , saline , sufentanil , analgesic , cholecystectomy , agonist , opioid , surgery , propofol , receptor , nociception
Remifentanil-induced hyperalgesia (RIH) is a paradoxical phenomenon that may increase sensitivity to painful stimuli. Nalbuphine, which is both a μ- receptor antagonist and κ- receptor agonist, may affect RIH. The aim of this study was to evaluate the effects of nalbuphine on RIH during laparoscopic cholecystectomy.